The evidence dilemma in genomic medicine. Health Affairs. Taylor BS, Ladanyi M. Clinical cancer genomics: how soon is now. Swanton C, Caldas C. From genomic landscapes to personalized cancer management- is there a road map? Ann NY Acad Sci. Phillips KA.
Improving radiotherapy in cancer treatment: Promises and challenges
Closing the evidence gap in the use of emerging testing technologies in clinical practice. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Translational research in cancer genetics: the road less traveled. Publ Health Genomics. Spitz M, Bondy ML. The evolving discipline of molecular epidemiology of cancer.
Molecular epidemiology and its current use in cancer management. Lancet Oncol. The behavioral response to personalized genetic information: will genetic risk profiles motivate individuals and families chose more healthful behaviors?
- Change Password.
- Nature (Vol. 430, No. 6999, 29 July 2004).
- Fundamentals of Classical Arabic.
- Algorithmic Number Theory: 9th International Symposium, ANTS-IX, Nancy, France, July 19-23, 2010. Proceedings!
- Peripheral biomarkers for pediatric brain tumors: current advancements and future challenges;
Ann Rev Publ Health. Condit CM. Public understandings of risks from gene-environment interaction in common diseases: implications for public communications. Dissemination and implementation research on community-based cancer prevention: a systematic review. Am J Prev Med. Comparative effectiveness research and genomic medicine: an evolving relationship for 21 st century medicine. The path to personalized medicine. N Engl J Med. The science of team science: overview of the field and introduction to the supplement. Analyzing national health reform strategies with a dynamic simulation model.
Am J Public Health. Avorn J.
In defense of pharmacoepidemiology: embracing the yin and the yang of drug research. Atkins D. Creating and synthesizing evidence with decision makers in mind.
Integrating evidence from clinical trials and other study designs. Med Care. Study designs for effectiveness and translation research: Identifying trade-offs. Institute of Medicine. The learning healthcare system. Washington D. Genomewide association studies: results from the first few years and potential implications for clinical medicine.
Log in to Wiley Online Library
Ann Rev Med. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone-receptor negative breast cancer in the general population. Nat Genet. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. A genomewide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q Sequence variants at 22q13 are associated with prostate cancer risk.
Cancer Res. A genomewide association study of lung cancer identifies a region of chromosome 15p15 associated with risk for adenocarcinoma. Am J Hum Genet. Genomewide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q Moasser MM. Targeting the function of the HER2 oncogene in human cancer therapeutics. Wang G, Kelley RK. KRAS mutational analysis for colorectal cancer. PLoS Curr. Systematic review: Anti epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer.
Ann Int Med. Brewer JK. Cancer prevention and screening practices among women at risk for hereditary breast and ovarian cancer after genetic counseling in the community setting. Fam Cancer. Cancer Epi Biom Prev. Will knowledge of gene-based colorectal cancer disease risk influence quality of life and screening behavior? Findings from a population-based study. Nutbeam D.
The evolving concept of health literacy. Soc Sci Med. Genetically decreased CYP2D6 and the risk of tobacco dependence: a prospective study of novice smokers. Tob Control. Beliefs about heritability of cancer and health information seeking and preventive behaviors. J Cancer Edu. Goodenberger M, Lindor NM. Lynch and MYH-associated polyposis: review and testing strategy. J Clin Gastroenterol.
EGAPP: Recommendation from the EGAPP working group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Agency for Healthcare Research Quality. Hereditary nonpolyposis colorectal cancer: diagnostic strategies and their implications. Mvundura M, Grosse SD, et al. Cost effectiveness of genetic testing strategies for Lynch syndrome among newly diagnosed cases of colorectal cancer. Generation after generation: exploring the psychological impact of providing genetic services through a cascading approach.
A national clinical decision support infrastructure to enable the widespread and consistent practice of genomic and personalized medicine. Realist review: A new method of systematic review designed for complex policy interventions. J Health Services Res and Policy.http://cars.cleantechnica.com/ecos-de-tragicomedia.php
Research Areas: Screening and Early Detection - National Cancer Institute
Glasgow RE. What types of evidence are most needed to advance behavioral medicine? Annals Behav Med. From evidence-based medicine to mechanism-based medicine: reviewing the role of pharmacogenetics. Int J Clin Pharmacol. Can tumor gene expression profiling improve outcomes in patients with breast cancer. Stakeholder perspectives on a risk-benefit framework for genetic testing. Publ Health Genom. Khoury MJ. Dealing with the evidence dilemma in genomics and personalized medicine.